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Principal Investigator:
Assoc Prof Liu Linbo NTU Singapore
Key Words: Optical Coherence Tomography (OCT), Confocal Microscopic Imaging Technology, Optical Microscopic, Microcirculation, Quantitative Blood Flow Assessment, Absolution Blood Flow Velocity, Ophthalmological Examination

This technology is an advancement in the realm of medical imaging, offering sophisticated solutions and devices utilizing advanced optical coherence tomography (OCT) and confocal imaging systems. The development efforts of this state-of-the-art imaging technology and device include optical, mechanical, electric circuit and software design, and pioneers wide-field, quantitative, and high-resolution capabilities, supports multi-mode functionality, achieves unprecedented levels of capillary details and hemodynamic information throughout large tissue areas. The specific capabilities include: 1. high-resolution wide-field (15 mm x 15 mm) imaging of tissue (e.g. retinal) capillary in one shot (~10 sec) at low cost; 2. Quantitative evaluation of absolute blood flow velocity / flux down to the capillary level over large field of view in human noninvasively and without use of a contrast agent.

Potential Applications

This advanced imaging system and device have a wide range of potential applications in the field of medical imaging, including ophthalmic and dermatological diagnostics, and assessment of microcirculations and hemodynamics of vascular bed in other types of tissues. For example,   in ophthalmology, this system visualizes and analyses various eye conditions such Diabetic Retinopath, Glaucoma, Macular Degeneration with unprecedented precision and accuracy. Its functions also enable the aid in the early detection and useful for examination for pediatric patients.

Value Proposition

The proposed technology is advantageous firstly in field of view and sampling density over the existing commercial products available in the market. The technology can overcome the limitations in signal to noise ratio (SNR) and transverse sampling density commonly occurred in OCTA. The proposed technology is the first in the world that can robustly measure absolute blood flow velocity / flux down to capillary level over large field of view. Finally but importantly, these advanced functionalities are achieved without significant increase in the cost compared with clinical routinely used devices, and in principle can be realized in the existing devices without modest hardware change.