This technology enables efficient extraction of collagen protein from bullfrog skin. Based on this, newly developed biomaterials and 3D scaffolds can be used as bone graft substitutes in dental implant procedures, promoting alveolar ridge preservation without the need for a bone membrane flap. The designed porous 3D structure also makes it suitable for tissue engineering applications, such as scaffolds for bone, cartilage, and other tissue regeneration, applicable to orthopedic and maxillofacial surgeries, promoting bone regeneration and integration.

The technology transforms food waste (bullfrog skin) to high-value material (collagen), it promotes sustainable practices, reducing the environmental impact of waste and contributing to the circular economy. The source material, bullfrog skin, has simple dietary requirements, and it can be harvested relatively quickly, reducing batch-to-batch variability.

Compared to current major market players, the developed biomaterials have advantages of excellent biocompatibility, ease of extraction, low-cost and lower risk of disease transmission. The designed porous architecture is ideal to enable cell infiltration from surrounding host tissue, ingrowth of blood vessels to support regeneration to damaged/ lost tissue and facilitate exchange of nutrients and metabolic wastes for the cells.