The project team has successfully developed a range of tool enzymes such as DNA polymerase, reverse transcriptase, ligase, transposase, and nuclease, as well as over 30 core raw enzymes for DNA/RNA testing and next-generation sequencing, which have been used by leading listed companies such as KingMed Diagnostics Group, Guangzhou Hybribio, and Wens Foodstuff Group. These products play a crucial role in healthcare by assisting in the diagnosis and treatment of infectious diseases, genetic disorders, and tumours. The developed technology and products can be used in other fields such as animal husbandry, food safety, and life science research.
The project team applies principles from molecular biology and structural biology, as well as bioengineering techniques such as genetic engineering and protein engineering, to conduct performance-oriented gene discovery, de novo protein design, and molecular modification of specialized enzymes for molecular diagnostics. It is dedicated to exploring biological enzymes with high catalytic efficiency, stability, and applicability. The project team has been exploring new high-performance enzymes for PCR, isothermal amplification, and gene sequencing, utilizing optimized buffer systems, as well as working on high-end products that can be applied for in vitro diagnostics, precision medicine, high-throughput sequencing, food safety testing, animal and plant inspection, quarantine, and life science research.
